| Thomas Middleditch | Richard Hendricks |
| Josh Brener | Nelson 'Big Head' Bighetti |
| Martin Starr | Bertram Gilfoyle |
| Kumail Nanjiani | Dinesh Chugtai |
| Amanda Crew | Monica Hall |
| Zach Woods | Donald 'Jared' Dunn |
| Matt Ross | Gavin Belson |
| Suzanne Cryer | Laurie Bream |
| Jimmy O. Yang | Jian Yang |
| Chris Diamantopoulos | Russ Hanneman
(credit only) |
| Neil Casey | Colin |
| Arturo Castro | Maximo Reyes |
| Ben Feldman | Ron LaFlamme |
| Bernie Kopell | Lex Skelton |
| Avi Nash | Wajid |
| Chris Williams | Hoover |
| Nandini Bapat | Gwart |
| Jacob Berger | Police Officer |
| David Bickford | Vaughn |
| Matt Kohler | Jay |
| Lou Richards | Lee |
| Damon Victor Allen | Triathlete
(uncredited) |
| Khalid Ghajji | Bodyguard #5
(uncredited) |