| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana Fisher |
| Richard Flood | Ford |
| Becca Blackwell | Father Murphy |
| Samantha Hanratty | Kassidi
(as Sammi Hanratty) |
| Ruby Modine | Sierra |
| Jessica Szohr | Nessa |
| Andy Umberger | Blake's Father |
| Maggie Wheeler | Lawyer |
| Jim Hoffmaster | Kermit |
| Michael Patrick McGill | Tommy |
| Karishma Ahluwalia | Dr. Patel |
| Christian Isaiah | Liam Gallagher |
| Tina Ivlev | Freelania Alexeyevich |
| Laird Macintosh | Andrew |
| Perry Mattfeld | Mel |
| Jeryl Prescott | Gabarieo |
| Billy 'Sly' Williams | Linc |
| Nicco Annan | Deacon Cook |
| Michael Armstead | Bic |
| Shaun T. Benjamin | Norman Morton |
| Joni Bovill | Desk Nurse |
| John Churchill | Skip |
| Danielle Davis | Sharon |
| Jack Essner | Blake |
| Ahmad Nicholas Ferguson | Drug Dealing Kid
(as Ahmad Ferguson) |
| Cooper J. Friedman | Lucas
(as Cooper Friedman) |
| Ryan Heindl | Benson |
| Jonathan LaVallee | Dr. Rob |
| Jackie Mah | Elma |
| Jennifer Manley | Gabarieo |
| Stacey Oristano | Trina |
| Nick Pietropaolo | Aviv |
| Scarlet Spencer | Xan |
| Levy Tran | Eddie |
| Jack Wallace | Rupert Sheffield |
| Preston Bradley | Furniture store employee
(uncredited) |
| Doby Daenger | Social Security Customer
(uncredited) |
| Jeff Dlugolecki | Dead Guy
(uncredited) |
| Michael I. Goode | Frandmore Patron
(uncredited) |
| Janis Jones | Social Security Client
(uncredited) |