| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana
(credit only) |
| Chloe Webb | Monica Gallagher |
| John Aylward | Bill |
| Scott Michael Campbell | Brad |
| Elliot Fletcher | Trevor |
| Kerri Kenney | Constance Grace |
| Ruby Modine | Sierra |
| Zack Pearlman | Neil |
| Barry Sloane | Ryan |
| David Fabrizio | Drill Instructor |
| Diandra Lyle | Dr. Caughey |
| Adele Daniller | Mildred |
| Brenden Sims | Liam |
| Richie Vetter | Adonis
(as Richard Vetter) |
| Julia Anna Barrios | Welding Student
(uncredited) |
| Jamison Bright | Military Chaplain
(uncredited) |
| Colleen Mooney | Nurse
(uncredited) |
| Alex Zelenka | Bus Passenger
(uncredited) |