| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher
(credit only) |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Noel Fisher | Mickey Milkovich |
| Emily Bergl | Sammi Slott |
| Dermot Mulroney | Sean Pierce |
| Steve Kazee | Gus Pfender |
| Sasha Alexander | Helene Runyon |
| Patrick Bristow | Bill |
| Michael Reilly Burke | Theo Wallace |
| Isidora Goreshter | Svetlana |
| Lenny Jacobson | Norbert |
| Bojana Novakovic | Bianca Samson |
| Chloe Webb | Monica Gallagher |
| Blake Boyd | Sergeant Nathan Kipps |
| Christopher Goodman | Clerk |
| Annie Little | Elizabeth |
| Michael Patrick McGill | Tommy |
| Brent Chase | Soldier 1 |
| Eric Franco | Soldier #2 |
| Miguel Izaguirre | Paco |
| Brooke Liz | Niece |
| Paul Blackwell | Prison Guard
(uncredited) |
| Brenden Sims | Liam Gallagher
(uncredited) |
| Joseph Wilson | Pedestrian
(uncredited) |