| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Noel Fisher | Mickey Milkovich |
| Emily Bergl | Sammi Slott |
| Joan Cusack | Sheila Jackson |
| Dermot Mulroney | Sean Pierce |
| Steve Kazee | Gus Pfender |
| Alessandra Ford Balazs | Jackie Scabello
(as Alessandra Balazs) |
| Emma Greenwell | Mandy Milkovich |
| Isidora Goreshter | Svetlana |
| Patrick Fischler | Wade Shelton |
| Axle Whitehead | Davis |
| Sheldon Bailey | Kenyatta
(as Shel Bailey) |
| Stacy Edwards | Laura Shelton |
| Nolan Freeman | Sully |
| Brad Grunberg | Tim |
| Michael Patrick McGill | Tommy |
| David St. James | Pastor |
| Danika Yarosh | Holly Herkimer |
| Jackson A. Dunn | Will |
| Raymond Forchion | Minister |
| J. Teddy Garces | Military Officer |
| Cole Hockenbury | Homeless Teen |
| Amy Honey | Meeting Secretary |
| John Marshall Jones | Lungs |
| Dean Li | Twink |
| Kyle Mattocks | Firefighter |
| Kellen Michael | Chuckie Slott |
| Kevin Quinn | 17 Year Old Boy |
| Amanda Reed | Jan |
| Wendy Rosoff | Corneas |
| Hector Atreyu Ruiz | Carlos |
| Sheila Shaw | Church Woman |
| Brenden Sims | Liam Gallagher |
| Christopher Stills | Chris
(as Chris Stills) |
| Zoe Tyson | 17 Year Old Girl |
| Jordan Webb | Muscle Head |
| Gunner Gadbois | Yevgeny |
| Ryder Gadbois | Yevgeny |
| Mark Casimir Dyniewicz Jr. | Diner Dino
(uncredited) |
| Christopher Kahler | Nerney
(uncredited) |
| Kaleb Shorey | Carl's Friend
(uncredited) |