| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher
(credit only) |
| Noel Fisher | Mickey Milkovich |
| Emma Greenwell | Mandy Milkovich |
| Jake McDorman | Mike Pratt |
| Joan Cusack | Sheila Jackson |
| Vanessa Bell Calloway | Carol Fisher |
| Jack Carter | Stan |
| Tyler Jacob Moore | Tony Markovich |
| Dennis Cockrum | Terry Milkovich |
| Isidora Goreshter | Svetlana |
| Joe Adler | Colin Milkovich |
| Bill Brochtrup | Hal |
| Maile Flanagan | Connie |
| James Allen McCune | Matty Baker |
| Rose Abdoo | Dr. Vega |
| Adam Cagley | Ron Kuzner |
| Kate Cobb | Jane Pratt |
| Paul James | T.A. |
| Lynn Ann Leveridge | Nancy Pratt |
| Michael Patrick McGill | Tommy |
| Danika Yarosh | Holly Herkimer |
| Sheldon Bailey | Kenyatta
(as Shel Bailey) |
| Nichole Sakura | Amanda
(as Nichole Bloom) |
| Chuck Carrington | Dan |
| Antonio D. Charity | Duncan |
| Steven M. Gagnon | Bill Pratt |
| Rene Moran | Jairo
(as Rene D. Moran) |
| Teresa Ornelas | Ellie |
| Maggie May Stabile | Student |
| Abram Teunissen | Wolf |
| James Chudnow | Commuter
(uncredited) |
| Jack Foley | Dewey
(uncredited) |
| Christopher Kahler | Nerney
(uncredited) |
| Mino Mackic | Detective
(uncredited) |
| Barbara Maleski | Bears Tailgater
(uncredited) |
| Denis Mulvihill | Tailgater
(uncredited) |
| Brenden Sims | Liam Gallagher
(uncredited) |
| Kitsy Smith | Student
(uncredited) |