| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Justin Chatwin | Jimmy |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Emma Greenwell | Mandy Milkovich |
| Zach McGowan | Jody Silverman |
| Joan Cusack | Sheila Jackson |
| Harry Hamlin | Lloyd 'Ned' Lishman |
| Stephanie Fantauzzi | Estefania |
| Ed Lauter | Dick Healey |
| Bernardo De Paula | Beto
(as Bernardo de Paula) |
| Pêpê Rapazote | Nando
(as Pepe Rapazote) |
| Lombardo Boyar | Manuel |
| Diora Baird | Meg |
| Thierre Di Castro Garrito | Marco
(as Thierre Di Castro) |
| Danny Mora | Judge Chapman Young |
| Tara Karsian | Celia |
| Alexander Aguila | El Cuchillo
(as Alexander Matthew Aguila) |
| Lauren Birriel | Alexa |
| John Bishop | Max |
| Josh Clark | Tacker |
| Robert Covarrubias | Good Samaritan |
| Sidow Sobrino | Coyote
(as Diego Diego) |
| Tobias Jelinek | Meth Head |
| Omar Leyva | Federale |
| Pete Ploszek | Goff |
| Noel Fisher | Mickey Milkovich |
| Paul Blackwell | Prison Guard
(uncredited) |
| Paul Douglas Brown | Janusz
(uncredited) |
| Elizabeth Reiners | Gold Coast Shopper
(uncredited) |
| William Rocha | Cartel Member
(uncredited) |
| Franklin Ruehl | Tourist
(uncredited) |
| Brenden Sims | Liam Gallagher
(uncredited) |
| Anthony James Whitewolf | Jesus Christ
(uncredited) |