| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Justin Chatwin | Steve |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Laura Wiggins | Karen Jackson
(as Laura Slade Wiggins) (credit only) |
| Joan Cusack | Sheila Jackson |
| Chloe Webb | Monica Gallagher |
| Zach McGowan | Jody Silverman |
| Stephanie Fantauzzi | Estefania |
| Emma Greenwell | Mandy Milkovich |
| Dennis Cockrum | Terry Milkovich |
| David Wells | Father Pete |
| Moshe Kasher | Ruben |
| Diora Baird | Meg |
| J.D. Mollison | GED Teacher
(as J.D. Goldblatt) |
| Thierre Di Castro Garrito | Marco
(as Thierre Di Castro) |
| J.P. Hubbell | Sergeant Stryker |
| Ellen Gerstein | Aunt Rande |
| Jack Impellizzeri | Hissrich |
| Bruno Amato | Dock Worker |
| Carl McDowell | Ricky |
| William Mulligan | Street Pedestrian
(uncredited) |
| Arthur-Angelo Sarinas | Neighbor
(uncredited) |
| Brenden Sims | Liam Gallagher
(uncredited) |