| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Justin Chatwin | Steve
(credit only) |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Laura Wiggins | Karen Jackson
(as Laura Slade Wiggins) |
| Joan Cusack | Sheila Jackson |
| James Wolk | Adam |
| Madison Davenport | Ethel |
| Marcus Brown | Pub Patron |
| Pej Vahdat | Kash |
| Emma Greenwell | Mandy Milkovich |
| Tyler Jacob Moore | Tony Markovich |
| Marguerite Moreau | Linda |
| Jack Carter | Stan |
| Dennis Boutsikaris | Professor Hearst |
| Amy Smart | Jasmine Hollander |
| Kerry O'Malley | Kate |
| Sammy A. Publes | Lt. Ruiz |
| Zach McGowan | Jody Silverman |
| Sue Gisser | Nikki |
| Casey Biggs | David |
| Christian Monzon | DJ Zafon |
| Zakiah Garcia | 1st Park Kid |
| Edgar Aslanyan | 2nd Park Kid
(as Edgar Arthur Aslanyan) |
| Presley A. Aronson | 3rd Park Kid |
| Hector Duran | Cigarettes Boy |
| Blake Burleson | Tough Kid |
| John Antonini | Young Banker |
| Thomas F. Evans | Johnny |
| Robert Gallo | Hugo |
| Tamara Rey | Le Club Lady
(as Tamara Camille) |
| Donovan Epison | Corner Drug Dealer |
| Johnnie Battistessa | Homeless Kid
(uncredited) |
| Stacey Elaine Jackson | Angry Mom
(uncredited) |
| Samuel Meadows | Bonfire Partier
(uncredited) |
| Rachel Rodewald | Kid in Line for the Movies
(uncredited) |