| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Justin Chatwin | Steve |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Joan Cusack | Sheila Jackson |
| Marguerite Moreau | Linda |
| Joel Murray | Eddie Jackson |
| Pej Vahdat | Kash |
| Laura Wiggins | Karen Jackson
(as Laura Slade Wiggins) |
| Noel Arthur | Bouncer |
| Charin Alvarez | Rita |
| Yves Bright | Customer 2 |
| Ben Cornish | Customer 1 |
| Thomas F. Duffy | Tommy |
| Sabah El-Amin | Waitress |
| Matt Eyde | Delivery Guy |
| Tyler Jacob Moore | Tony Markovich |
| Patrick Sarb | Aston Martin Guy |
| Leslie Thurston | Woman |
| Joseph Alfieri | Angry Hockey Fan
(uncredited) |
| Randy Bernales | Businessman
(uncredited) |
| Nelson Carvajal | Neighbor
(uncredited) |
| Joe DeBartolo | Neighbor
(uncredited) |
| Jay Disney | Cop
(uncredited) |
| Shannon Edwards | Neighbor
(uncredited) |
| Bill Ibrahim | Restaurant Patron
(uncredited) |
| Blake Alexander Johnson | Liam Gallagher
(uncredited) |
| Christopher Kimball | Self - TV Chef
(archive footage) (uncredited) |
| Bridget Lancaster | Self - TV Chef
(archive footage) (uncredited) |
| Damian Forest Light | Bar /
Club Patron
(uncredited) |
| Joseph McGreal | Chicago Police Officer
(uncredited) |
| William Nero Jr. | Neighborhood Kid
(uncredited) |
| Evie Nicholson | Cocktail Waitress Esther
(uncredited) |
| Bryan C. Ordman | Guy Flicking off Cops
(uncredited) |
| James Pusztay | Commuter
(uncredited) |
| Kyle Sauer | Club Goer
(uncredited) |