| William H. Macy | Frank Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Noel Fisher | Mickey Milkovich |
| Christian Isaiah | Liam Gallagher |
| Kate Miner | Tami Tamietti |
| Rachel Dratch | Paula Bitterman |
| Elizabeth Rodriguez | Faye Donahue |
| Constance Zimmer | Claudia Nicolo |
| Maya Bednarek | Stella |
| Sarah Colonna | Lori |
| Elise Eberle | Sandy Milkovich |
| Jess Gabor | Kelly Keefe |
| Dylan Gelula | Megan |
| Danube Hermosillo | Pepa |
| Nicki Micheaux | Michelle 'Shelly' Demeter |
| Jim Hoffmaster | Kermit |
| Michael Patrick McGill | Tommy |
| Eddie Alfano | K.J. |
| John Lee Ames | Caleefa |
| Tiffany Renee Johnson | Gloria Johnson |
| Katherine Mitchell | Ester |
| Stephanie 'Stevvi' Alexander | Kendall |
| Lewie Bartone | Jerry |
| David Bowe | Bob Tamietti |
| Edward Bossert | Haiku |
| Bobby Bromley | Gus |
| Brandon Paul Eells | Gil |
| Dan Gilvezan | Mark |
| Emily Kimball | Amber |
| Jason McBeth | Stump |
| Miluette Nalin | Hilda |
| Alyssa Gabrielle Rodriguez | Jennie |
| Matt Riedy | Charles |
| Clara Baker-Ringo | Bella |
| Cameron Sanders | Nelson |
| Paris Newton | Franny Gallagher
(uncredited) |
| Bill Reilly | Bus Passenger
(uncredited) |
| Rekkhan | Pedestrian
(uncredited) |