| Angie Harmon | Jane Rizzoli |
| Sasha Alexander | Maura Isles |
| Brian Goodman | Lieutenant Sean Cavanaugh |
| Jordan Bridges | Frankie Rizzoli Jr. |
| Lee Thompson Young | Barry Frost |
| Bruce McGill | Vince Korsak |
| Lorraine Bracco | Angela Rizzoli |
| Amaury Nolasco | Lt. Det. Rafael Martinez |
| Chris Vance | Lt. Col. Charles 'Casey' Jones |
| Chris Tallman | David Sutton |
| Samantha Hanratty | Chloe |
| Leah Bateman | Emma |
| Piper Curda | Megan |
| Vanessa Bell Calloway | Assistant District Attorney |
| Tricia Leigh Fisher | Mrs. Cole |
| Tina Huang | Susie Chang |
| Andrea Bordeaux | Neda |
| Kevin Rock | Principal Roger Appleton |
| Meryl Hathaway | Mrs. Sutton |
| Alexis Raich | Samantha Cole |
| Christopher May | Mr. Cole |
| Dyana Liu | Karine Alberts |
| Paxton the Dog | Jo Friday |
| M.J. Dougherty | Woman Rater |
| Zoran Jacimovic | Police Officer |