| K.J. Apa | Archie Andrews |
| Lili Reinhart | Betty Cooper |
| Camila Mendes | Veronica Lodge |
| Cole Sprouse | Jughead Jones |
| Marisol Nichols | Hermione Lodge |
| Madelaine Petsch | Cheryl Blossom |
| Mark Consuelos | Hiram Lodge |
| Casey Cott | Kevin Keller |
| Charles Melton | Reggie Mantle |
| Vanessa Morgan | Toni Topaz |
| Skeet Ulrich | FP Jones |
| Mädchen Amick | Alice Cooper |
| Martin Cummins | Tom Keller |
| Wyatt Nash | Charles Smith |
| Kerr Smith | Principal Holden Honey |
| Jordan Connor | Sweet Pea |
| Trinity Likins | Jellybean Jones |
| Alvin Sanders | Pop Tate |
| Drew Ray Tanner | Fangs Fogarty |
| Barbara Wallace | Rose Blossom |
| Brendan O'Brien | Math Teacher |
| Marion Eisman | Doris Bell |
| Randa Barett | Dancer |
| Josh Bogert | Randon Number Generation Singer |
| Danielle Brokopp | Tear Me Down Dancer |
| Cassandra Consiglio | Random Number Generation Dancer |
| Mariesa Crouse | Random Number Generation Dancer |
| Alex Gullason | Singer |
| Charlotte Kavanagh | Dancer |
| Luke Perry | Fred Andrews |
| Brandon Vick | South Side Serpent |
| Ross Wirtanen | Student Chorus |