| Patrick Stewart | Capt. Jean-Luc Picard /
Locutus of Borg |
| Jonathan Frakes | Cmdr. William Riker |
| LeVar Burton | Lt. Cmdr. Geordi La Forge |
| Michael Dorn | Lt. Worf |
| Gates McFadden | Dr. Beverly Crusher |
| Marina Sirtis | Counselor Deanna Troi |
| Brent Spiner | Lt. Cmdr. Data |
| Wil Wheaton | Ensign Wesley Crusher |
| Elizabeth Dennehy | Lt. Cmdr. Shelby |
| George Murdock | Adm. J. P. Hanson |
| Colm Meaney | Chief Miles O'Brien |
| Whoopi Goldberg | Guinan |
| Todd Merrill | Gleason |
| Rachen Assapiomonwait | Crewman
(uncredited) |
| Majel Barrett | Enterprise Computer
(voice) (uncredited) |
| Debbie David | Ensign Russell
(uncredited) |
| Eben Ham | Operations Division Ensign
(uncredited) |
| Randy James | Jones
(uncredited) |
| Mark Lentry | Science Division Officer
(uncredited) |
| Tim McCormack | Ensign Bennett
(uncredited) |
| Kip Reynolds | Borg
(uncredited) |
| Lincoln Simonds | Security Officer
(uncredited) |
| Adrian Tafoya | Borg
(uncredited) |
| Natalie Wood | Bailey
(uncredited) |