| Patrick Stewart | Capt. Jean-Luc Picard |
| Jonathan Frakes | Cmdr. William Riker |
| LeVar Burton | Lt. Geordi La Forge |
| Michael Dorn | Lt. Worf |
| Marina Sirtis | Counselor Deanna Troi |
| Brent Spiner | Lt. Cmdr. Data |
| Wil Wheaton | Wesley Crusher |
| Diana Muldaur | Doctor Pulaski |
| Christopher Collins | Capt. Grebnedlog |
| Leslie Morris | Cmdr. Reginod |
| Daniel Benzali | Surgeon |
| Lycia Naff | Ensign Sonya Gomez |
| Tzi Ma | Biomolecular Physiologist |
| Bill Ames | Pakled Crew Member
(uncredited) |
| Majel Barrett | Enterprise Computer
(voice) (uncredited) |
| Robert J. Feldman | Pakled Crew Member
(uncredited) |
| Victor A. Haddox | Pakled Crew Member
(uncredited) |
| Tim McCormack | Ensign Bennett
(uncredited) |
| T.J. McGee | Assistant surgeon
(uncredited) |