| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows |
| Wade Williams | Brad Bellick |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| John Heard | Governor Frank Tancredi |
| Frank Grillo | Nick Savrinn |
| Lane Garrison | David 'Tweener' Apolskis |
| Matt DeCaro | Corrections Officer Roy Geary |
| Tracy Letts | Peter Tucci |
| Patricia Wettig | Vice President Caroline Reynolds |
| Stacy Keach | Warden Henry Pope |
| Phil Ridarelli | Lyle |
| Joel Hatch | Judge Randall Kessler |
| Phillip Edward Van Lear | Louis Patterson |
| Christian Stolte | Corrections Officer Keith Stolte |
| Mark Morettini | C.O. Rizzo Green |
| Antoine McKay | C.O. Antoine Roy |
| Mac Brandt | Corrections Officer Mack Andrews Andrews |
| Terry Berner | Electrician |
| Robin Robinson | Interviewer |
| Kurt Naebig | C.O. #1 |
| Bruce A. Young | C.O. #2 |
| Ray Austin | C.O. #4 |
| Dennis Janiske | Inmate |
| Tim Krueger | Secret Service Agent |
| Zachary Laoutides | Prisoner |
| Dylan Minnette | Young Michael |
| Gary Sedlock | Inmate Walking Next to Michael |
| John Stacho | Courtroom Reporter |
| Chuck Wagner | Dayplayer |