| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Peter Stormare | John Abruzzi |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Frank Grillo | Nick Savrinn |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Danny McCarthy | Daniel Hale |
| Lane Garrison | David 'Tweener' Apolskis |
| Camille Guaty | Maricruz Delgado |
| Matt DeCaro | Corrections Officer Roy Geary |
| Stacy Keach | Warden Henry Pope |
| Phillip Edward Van Lear | Louis Patterson |
| Rich Komenich | Maggio |
| Tom McElroy | Reverend Mailor |
| Larry Neumann Jr. | Jimmy Bagwell |
| Christian Stolte | Corrections Officer Keith Stolte |
| Anthony Fleming | Trumpets |
| Bobby Linkhart | Jimmy Bagwell Jr. |
| Jenny Kern | Allison Hale |
| Ian Belknap | Interviewer |
| Jim Zulevic | ER Doctor |
| James McCammond | Another Goon |
| Zachary Laoutides | Prisoner |
| John Lister | R & D Officer |
| Tom Lowell | Cronie #1 |
| Chris Nolte | Abruzzi Cronie |
| Angelina Riposta | Cafe Patron |
| Joyce Thurston | Prison Vistor |