| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Peter Stormare | John Abruzzi |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Frank Grillo | Nick Savrinn |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Danny McCarthy | Daniel Hale |
| Lane Garrison | David 'Tweener' Apolskis |
| Holly Valance | Nika Volek |
| Michael Gaston | Quinn |
| Matt DeCaro | Corrections Officer Roy Geary |
| Stacy Keach | Warden Henry Pope |
| Phillip Edward Van Lear | Louis Patterson |
| DuShon Monique Brown | Nurse Katie Welch |
| Mac Brandt | Corrections Officer Mack Andrews |
| Sephus Booker | C.O. |
| Dado Rothenberg | Female Guard |
| Javon Johnson | Frisk Room C.O. |
| John Lister | R & D Officer |
| Antoine McKay | Guard |
| Julia Sobaski | Woman Dancer |
| John Carter Brown | Salesman |
| Zachary Laoutides | Prisoner |
| Joseph A Olivera | Corrections Officer |
| John Quilico | PI Inmate |