| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Peter Stormare | John Abruzzi |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Frank Grillo | Nick Savrinn |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Danny McCarthy | Daniel Hale |
| Peter J. Reineman | Gus Fiorello |
| Al Sapienza | Philly Falzone |
| Holly Valance | Nika Volek |
| Michael Gaston | Quinn |
| Anthony Starke | Sebastian Balfour |
| Patricia Wettig | Vice President Caroline Reynolds |
| Roderick Peeples | Otto Fibonacci |
| Gianni Russo | Gavin Smallhouse |
| Annabel Armour | Fibonacci's Wife |
| Tom McElroy | Chapel Priest |
| Phillip Edward Van Lear | Louis Patterson |
| Christian Stolte | Corrections Officer Keith Stolte |
| Nickolas Loquercio | LJ Age 5 |
| Robin Robinson | News Reporter |
| Mark Vallarta | Mobster #1 |
| Keith Kupferer | Inmate Jersey |
| Matt Zeigler | Speech Writer |
| Laura Wade | Tattoo Artist |
| Brent Allen Caputo | Secret Service |
| Nick Doetsch | Abruzzi's Ex-Thug |
| Eddie J. Fernandez | Abruzzi Cronie #3 |
| Zachary Laoutides | Prisoner |
| Tom Lowell | Cronie #1 |
| William Nero Sr. | Police Officer |
| Chris Nolte | Abruzzi Cronie |