| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Peter Stormare | John Abruzzi |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Sarah Wayne Callies | Sara Tancredi |
| Jessalyn Gilsig | Lisa Rix |
| Al Sapienza | Philly Falzone |
| Anthony Starke | Sebastian Balfour |
| Adina Porter | Leticia Barris |
| Silas Weir Mitchell | Charles 'Haywire' Patoshik |
| Danny McCarthy | Daniel Hale |
| Stacy Keach | Warden Henry Pope |
| Wesley Walker | Aryan Brother |
| Peter J. Reineman | Gus Fiorello |
| Sandra Marquez | Mrs. Delgado |
| Linara Washington | Jenae Conlin |
| Tom McElroy | Reverend Mailor |
| Mac Brandt | Corrections Officer Mack Andrews |
| Phillip Edward Van Lear | Louis Patterson |
| Christian Stolte | Corrections Officer Keith Stolte |
| Tab Baker | Crab Simmons |
| Jason Wells | Bo - White Cap |
| Lillian Almaguer | John Abruzzi's Daughter |
| Elijah Roberts | John Abruzzi's Son |
| Tracey Bonner | Old African American Lady |
| Michael L. Howard | Inmate |
| Theophilus Jamal | Inmate |
| Zachary Laoutides | Prisoner |
| Tom Lowell | Cronie |
| Mark Morettini | Correctional Officer Rizzo Green |
| Chris Nolte | Abruzzi Cronie |
| Chris Papadopoulos | Inmate |
| David Dino Wells Jr. | Turner |
| James Zahn | Inmate |
| Niko El Santo Zavero | Prisoner |