| Taylor Schilling | Piper Chapman |
| Natasha Lyonne | Nicky Nichols |
| Uzo Aduba | Suzanne 'Crazy Eyes' Warren |
| Danielle Brooks | Tasha 'Taystee' Jefferson |
| Jackie Cruz | Marisol 'Flaca' Gonzales |
| Laura Gómez | Blanca Flores |
| Selenis Leyva | Gloria Mendoza |
| Taryn Manning | Tiffany 'Pennsatucky' Doggett |
| Adrienne C. Moore | Cindy Hayes |
| Matt Peters | Joel Luschek |
| Jessica Pimentel | Maria Ruiz |
| Dascha Polanco | Dayanara Diaz |
| Alysia Reiner | Natalie Figueroa |
| Elizabeth Rodriguez | Aleida Diaz |
| Nick Sandow | Joe Caputo |
| Dale Soules | Frieda Berlin |
| Yael Stone | Lorna Morello |
| Kate Mulgrew | Galina 'Red' Reznikov |
| Laura Prepon | Alex Vause |
| Catherine Curtin | Wanda Bell |
| Daniella De Jesús | Zirconia Cabrera |
| Nick Dillenburg | CO Ryder Blake |
| Beth Dover | Linda Ferguson |
| Hunter Emery | CO Rick Hopper |
| Joel Marsh Garland | Scott O'Neill |
| Shawna Hamic | CO Virginia 'Ginger' Copeland |
| Susan Heyward | Tamika Ward |
| Mike Houston | CO Lee Dixon |
| John Magaro | Vince Muccio |
| Sipiwe Moyo | Adeola |
| Deborah Rush | Carol Chapman |
| Emily Tarver | CO Artesian McCullough |
| Christina Toth | Annalisa Damiva |
| Alicia Witt | Zelda |
| Laverne Cox | Sophia Burset |
| Phumzile Sitole | Akers |
| Besanya Santiago | Creech |
| Tuli Roy-Kirwan | Swapna Majumdar |
| Marie-Lou Nahhas | Shani Abboud |
| Karina Arroyave | Karla Córdova |
| Ismenia Mendes | Tali Grapes |
| Adam Lindo | Carlos 'Clitvack' Litvack |
| Alysia Joy Powell | Wyndolyn Capers |
| Manny Ureña | Dean 'Junior' Juarez |
| Melinna Bobadilla | Santos Chaj |
| Bob Stoeckle | Dr. Hirt |
| Angela Lanza | Louise |
| Hend Ayoub | Mona |
| Farah Bala | Dr. Hakakha |
| Pun Bandhu | Mitchell Kanter |
| Matthew Leone | Karim |
| Cate Bottiglione | Foster Mother Pat |
| Christian A Guerrero | ICE Air Agent Miller |
| Colton Hirt | Santi #1 |
| Braxton Hirt | Santi #2 |
| Jaxli Rae Hirt | Alma |
| Keren Lugo | Luz |
| Laith Nakli | Youssef |
| Marisa Redanty | Judge Christine Holister |
| Jeter Rivera | Benji |
| Ky Soto | Andy |
| Byron Tzoc | Byron |
| Darren Valinotti | Abel |
| Tyler A. Griffin | Julio |
| Juan Blasquez | El Trompiz |
| Antonio Mardoqueo Chaj Oxlaj | Miguel |
| Gloria Sandoval | Woman |
| Pablo Soriano | Man |
| Carla Carvalho | Ice Detainee |
| Nikki Exotika | Gala Guest |
| Courtney Gonzalez | D-Block Inmate |
| Claudette Lalí | Inmate |
| Annie Pisapia | Inmate |