| Taylor Schilling | Piper Chapman |
| Natasha Lyonne | Nicky Nichols |
| Uzo Aduba | Suzanne 'Crazy Eyes' Warren |
| Danielle Brooks | Tasha 'Taystee' Jefferson |
| Jackie Cruz | Marisol 'Flaca' Gonzales |
| Laura Gómez | Blanca Flores |
| Selenis Leyva | Gloria Mendoza |
| Taryn Manning | Tiffany 'Pennsatucky' Doggett |
| Adrienne C. Moore | Cindy Hayes |
| Matt Peters | Joel Luschek |
| Jessica Pimentel | Maria Ruiz |
| Dascha Polanco | Dayanara Diaz |
| Elizabeth Rodriguez | Aleida Diaz |
| Nick Sandow | Joe Caputo |
| Dale Soules | Frieda Berlin |
| Yael Stone | Lorna Morello |
| Kate Mulgrew | Galina 'Red' Reznikov |
| Laura Prepon | Alex Vause |
| Jason Altman | Herrmann |
| Michael Chernus | Cal Chapman |
| Laverne Cox | Sophia Burset |
| Marcia DeBonis | Cathy |
| Daniella De Jesús | Zirconia Cabrera |
| Nick Dillenburg | CO Ryder Blake |
| Beth Dover | Linda Ferguson |
| Tibor Feldman | Judge Arthur Franklin |
| Amanda Fuller | Badison Murphy |
| Susan Heyward | Tamika Ward |
| Alice Kremelberg | Nicole Eckelcamp |
| Maggie Lacey | Prosecutor |
| Mackenzie Phillips | Barbara Denning |
| Alysia Reiner | Natalie Figueroa |
| Peter Rini | Jason Figueroa |
| Shirley Roeca | Juanita Vazquez |
| Josh Segarra | CO Stefanovic |
| Emily Tarver | CO Artesian McCullough |
| Nicholas Webber | CO Alvarez |
| Tanya Wright | Crystal Burset |
| Sipiwe Moyo | Adeola |
| Besanya Santiago | Creech |
| Shawna Hamic | CO Virginia 'Ginger' Copeland |
| Greg Vrotsos | CO Hellman |
| Hunter Emery | CO Rick Hopper |
| Branden Wellington | CO Jarod Young |
| Miguel Izaguirre | Diablo |
| Vicci Martinez | Dominga 'Daddy' Duarte |
| Henny Russell | Carol Denning |
| Phumzile Sitole | Akers |
| Christina Toth | Annalisa Damiva |
| Reema Sampat | Shruti Chambal |
| Jo Lampert | Marie Brock |
| Rebecca Knox | Tina Swope |
| Nedra Marie Taylor | Sylvia Guillen |
| Naomi Lorrain | Kelly Lee Glenna |
| Dana Berger | Crystal Tawney |
| Lauren Kelston | Young Barbara |
| Ashley Jordyn | Young Carol |
| Evander Duck Jr. | Case Manager Bernard Whittles |
| Orease Bowers | Federal Marshal |
| Jen Keefe | Alicia Hutton |
| Lillian O'Shaughnessy | Bailiff |
| Michael J. Burg | Mark Bellamy |
| Sheila Head | Jury Foreperson |
| Nhadya Salomon | Dorothy |
| Hannah D. Scott | Aimee Sandoval |
| Becca GT | Amy Roth |
| Tiffany Jaide Hightower | Arrestee |
| Art Shrian Tiwari | Prison Executive |