| Edie Falco | Jackie Peyton |
| Merritt Wever | Zoey Barkow |
| Paul Schulze | Eddie Walzer |
| Dominic Fumusa | Kevin Peyton |
| Anna Deavere Smith | Gloria Akalitus |
| Stephen Wallem | Thor Lundgren |
| Betty Gilpin | Dr. Carrie Roman |
| Adam Ferrara | Frank Verelli |
| Ruby Jerins | Grace Peyton |
| Mackenzie Aladjem | Fiona Peyton |
| Peter Facinelli | Dr. Fitch Cooper |
| Julie White | Antoinette |
| Celia Keenan-Bolger | Goth patient |
| Julia Goldani Telles | Mandy |
| Joe Avellar | Weatherman |
| Paul Castree | Singing Hospital Employee #1 |
| Michelle Pereira | Singing Hospital Employee #2 |
| Brenda Braxton | Singing Hospital Employee #3 |
| Harry L. Seddon | Hospital Transporter |
| Roger Brenner | FDNY |
| Katherine Kine' | Nurse |