| Ryan Eggold | Dr. Max Goodwin |
| Janet Montgomery | Dr. Lauren Bloom |
| Freema Agyeman | Dr. Helen Sharpe |
| Jocko Sims | Dr. Floyd Reynolds |
| Tyler Labine | Dr. Iggy Frome |
| Michelle Forbes | Dr. Veronica Fuentes |
| Amaia Arana | ED Resident Roxana Zamaya |
| Megan Byrne | Gladys |
| Sasha Diamond | Dr. Wandy Agliar |
| Mike Doyle | Martin McIntyre |
| Alejandro Hernandez | Casey Acosta |
| Matthew Jeffers | Dr. Mark Walsh |
| Shiva Kalaiselvan | Leyla |
| Naiya Ortiz | Imani Moore |
| Frances Turner | Dr. Lyn Malvo |
| Debra Monk | Karen Brantley |
| Em Grosland | ED Nurse Brunstetter |
| Leah John | Sylvie Varden |
| Ash Spencer | Cee |
| Nora Clow | Luna |
| Opal Clow | Luna |
| Jackson Mercado | Ronald Elgin |
| Dan Godlin | Tyler Grice |
| Isaiah Seward | Paramedic Durango |
| Teresa Patel | Paramedic Harvell |
| Stacey Raymond | Paramedic Whitaker |
| Akram Basuni | Paramedic Nazari |
| Michael Basile | Paramedic Moreland |
| Mahalet Dejene | Anesthesiologist Nyala Abebe |
| Michael Chenevert | Nico Moore |
| Noelle LuSane | Cora Moore |
| Fay Ann Lee | Lead Attorney Jiang |
| Rajesh Bose | Dr. Rahul Nagendran |
| Deepti Kingra-Mickelsen | Bride |
| Julian Fadullon | Nurse Lin |
| Simone Vysnovsky | Student at a science fair |