| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Rodríguez Orejuela |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodríguez Orejuela |
| Pêpê Rapazote | Chepe Santacruz Londoño |
| Arturo Castro | David Rodriguez |
| Matias Varela | Jorge Salcedo |
| Michael Stahl-David | Chris Feistl |
| Matt Whelan | Daniel Van Ness |
| Javier Cámara | Guillermo Pallomari |
| Andrea Londo | Maria Salazar |
| Edward James Olmos | Chucho Peña |
| Brett Cullen | Arthur Crosby |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Roberto Cano | Dario |
| Gastón Velandia | General Serrano
(as Gaston Velandia) |
| Taliana Vargas | Paola Salcedo |
| Lina Castrillón | Patricia Pallomari |
| David Valencia | Fredy |
| Vicky Hernández | Gerda Salazar |
| Daniel Merizalde | Pinchadito |
| Matthew Glave | Mike Spencer |
| Brian Guest | Asst. U.S. Attorney |
| Maurho Jimenez | Manuel
(as Maurho Jiménez) |
| Nestor Sastoque | Prison Warden |
| César Vargas | Gonzalo Espedes
(as Cesar Vargas) |
| Andrés Franco | Emilio Salazar |
| Fabian Martínez | Gunman 1 |
| Fabio Mugno | Gunman 2 |
| Sindy Alexis Baquero | Receptionist |
| Damaris Garcia | Motorcycle Girl 1 |
| Isabella Rodríguez | Strip Club Waitress |
| Juana Álvarez | Vera Salcedo |
| Juan Manuel Diaz | Corporate Jet Rep |
| Alejandra Fernández Florez | Tele-Co Worker |
| Juan Angulo | Pancho's Gunman |
| Paul Marks | Judge |
| Kateri Garcia | Prosecutor |
| Jose Lizarde Jr. | Cartel Leader
(uncredited) |