| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Rodríguez Orejuela |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodríguez Orejuela |
| Pêpê Rapazote | Chepe Santacruz Londoño |
| Matias Varela | Jorge Salcedo |
| Javier Cámara | Guillermo Pallomari |
| Arturo Castro | David Rodriguez |
| Michael Stahl-David | Chris Feistl |
| Matt Whelan | Daniel Van Ness |
| Kerry Bishé | Christina Jurado |
| Andrea Londo | Maria Salazar |
| José María Yazpik | Amado Carrillo Fuentes
(as José María Yázpik) |
| Brett Cullen | Arthur Crosby |
| Miguel Ángel Silvestre | Franklin Jurado |
| Wayne Knight | Alan Starkman |
| Sebastian Eslava | Nicolas Rodriguez |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Carrell Lasso | Enrique |
| Roberto Cano | Dario |
| Edgar Prada | Alvaro Herrera |
| Lux Pascal | Elias
(as Lucas Balmaceda Pascal) |
| Gabriel Sloyer | Manuel de Dios Unane |
| Taliana Vargas | Paola Salcedo |
| Julián Arango | Orlando Henao |
| Girolly Gutierrez | Wilber Varela
(as Girolly Gutiérrez) |
| Vicky Hernández | Gerda |
| Carlos Rios | Duvan Salazar |
| Jaime Arango | Raul Salazar |
| Raymond Ablack | Stoddard |
| Sebastian Chacon | Rico
(as Stephen Chacon) |
| Aldo Uribe | Traqueto |
| Susana Victoria | Amparo
(as Susana Victoria Pérez) |
| Christophe de Geest | Commissioner |
| Lina Castrillón | Patricia Pallomari |
| Bella Barragán | Alma Salcedo |
| Juana Álvarez | Vera Salcedo |
| Jimmy Cristancho López | Doorman |
| Adriana Silva | Newswoman |
| Tatu Jokila | Agent Samuels |
| Maria Fernanda Briceño Cano | Stylist |
| Anddy Caicedo | Gahagen |
| Bobby Daniel Rodriguez | Man in Diner |
| Wendy Susan Hammer | Waitress |
| Idalia Limón | NY traqueta |
| Jose Lizarde Jr. | Cartel Leader
(uncredited) |