| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Rodríguez Orejuela |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodríguez Orejuela |
| Pêpê Rapazote | Chepe Santacruz Londoño |
| Matias Varela | Jorge Salcedo |
| Arturo Castro | David Rodriguez |
| Michael Stahl-David | Chris Feistl |
| Matt Whelan | Daniel Van Ness |
| Kerry Bishé | Christina Jurado |
| Andrea Londo | Maria Salazar |
| José María Yazpik | Amado Carrillo Fuentes
(as José María Yázpik) |
| Brett Cullen | Arthur Crosby |
| Miguel Ángel Silvestre | Franklin Jurado |
| Andrés Crespo | Carlo Córdova |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Carrell Lasso | Enrique |
| Roberto Cano | Darío |
| Juan Carlos Messier | Gustavo Calderon
(as Juan Messier) |
| Sebastian Eslava | Nicolas Rodriguez |
| Taliana Vargas | Paola Salcedo |
| Raymond Ablack | Stoddard |
| Julián Arango | Orlando Henao |
| Girolly Gutierrez | Wilber Varela
(as Girolly Gutiérrez) |
| Edgar Prada | Alvaro Herrera |
| Luis Mesa | Fernando Botero |
| Gustavo Ángel | Santiago Medina |
| Álvaro García | General Diego Vargas |
| Luis Eduardo Motoa | Bernardo Gonzales |
| Daniel Merizalde | Pinchadito |
| Cristian Sarmiento | Fercho |
| Jerónimo Barón | Pedro Salazar |
| Bella Barragán | Alma Salcedo |
| Juana Álvarez | Vera Salcedo |
| Yacko Márquez | Bartender |
| Nusret Gökçe | Nusret Gökçe |
| Jose Lizarde Jr. | Cartel Leader
(uncredited) |