| Wagner Moura | Pablo Escobar |
| Boyd Holbrook | Steve Murphy |
| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Rodríguez Orejuela |
| Paulina Gaitan | Tata Escobar
(as Paulina Gaitán) |
| Bruno Bichir | Fernando Duque |
| Paulina García | Hermilda Gaviria |
| Cristina Umaña | Judy Moncada |
| Francisco Denis | Miguel Rodríguez Orejuela |
| Alberto Ammann | Pacho Herrera |
| Raúl Méndez | César Gaviria |
| Florencia Lozano | Claudia Messina |
| Joanna Christie | Connie Murphy |
| Diego Cataño | La Quica |
| Martina García | Maritza |
| Leynar Gomez | Limon |
| Brett Cullen | Arthur Crosby |
| Konstantin Melikhov | Edward Jacoby |
| Jon-Michael Ecker | The Lion
(as Jon Ecker) |
| Jorge Monterrosa | Trujillo
(as Jorge Monterroza) |
| Alejandro Buitrago | Velasco |
| Julián Díaz | Blackie |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Federico Rivera | Ricardo Prisco |
| Andres Felipe Torres | Carlos Henao
(as Andrés Felipe Torres) |
| Mauricio Cujar | Don Berna |
| Mauricio Mejía | Carlos Castaño |
| Gustavo Angarita Jr. | Fidel Castaño
(as Gustavo Angarita) |
| Juan Pablo Shuk | Colonel Martinez |
| Sebastian Vega | Hugo Martinez Jr.
(as Sebastián Vega) |
| Germán Jaramillo | Gustavo De Greiff |
| Juan Murcia | Juan Pablo Escobar
(as Juan Sebastián Murcia) |
| María José Sanchez Real | Manuela
(as María José Sánchez) |
| Maruia Shelton | Juliana Carrillo |
| Carlos Mariño | Rojas |
| Yesi García | Manuel |
| Camilo Amores | Cesar |
| Álvaro García | Vargas Silva
(as Alvaro Trujillo) |
| Alejandro Gutiérrez | Presidential Aide |
| Beatriz Ramirez | De Greiff's Secretary |
| Ernesto Ballén | Young Sicario
(as Ernesto Ballen) |
| Juan Jose Aguirre | Servant |
| Santiago Urbina | Sicario #3 |
| Carlos Paez Buitrago | Drug dealer |
| Muratcan Savci | Fiscal de Muratcan |