| Wagner Moura | Pablo Escobar |
| Boyd Holbrook | Steve Murphy |
| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Orejuela |
| Paulina Gaitan | Tata Escobar
(as Paulina Gaitán) |
| Raúl Méndez | César Gaviria |
| Manolo Cardona | Eduardo Sandoval |
| Cristina Umaña | Judy Moncada |
| Bruno Bichir | Fernando Duque |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodriguez |
| Florencia Lozano | Claudia Messina |
| Joanna Christie | Connie Murphy |
| Eric Lange | Bill Stechner |
| Diego Cataño | La Quica |
| Leynar Gomez | Limon |
| Maurice Compte | Horacio Carrillo |
| Martina GarcÃa | Maritza |
| Konstantin Melikhov | Edward Jacoby |
| Brett Cullen | Arthur Crosby |
| Jorge Monterrosa | Trujillo
(as Jorge Monterroza) |
| Alejandro Buitrago | Velasco |
| Julián DÃaz | Blackie |
| Jairo Ordoñez | Jairo |
| Juan Sebastián Calero | Navegante |
| Germán Jaramillo | Gustavo De Greiff
(as German Jaramillo) |
| Mauricio Cujar | Don Berna |
| Mauricio MejÃa | Carlos Castaño
(as Mauricio Meija) |
| Gustavo Angarita Jr. | Fidel Castaño
(as Gustavo Angarita) |
| Federico Rivera | Ricardo Prisco |
| Leonardo GarcÃa Vale | Edgar Prisco
(as Leonardo GarcÃa) |
| Juan Murcia | Juan Pablo Escobar
(as Juan Sebastian Murcia) |
| MarÃa José Sanchez Real | Manuela
(as MarÃa José Sánchez) |
| DarÃo Cifuentes | David
(as Dario Cifuentes) |
| Carolina Acevedo | Gabriela |
| Alejandra Crispin | Gaviria's Secretary |
| Sandra Ardila | Maritza's Mother |
| Luis Enrique Gomez | Jesus Castaño |
| Muratcan Savci | Fiscal de Muratcan |