| Wagner Moura | Pablo Escobar |
| Boyd Holbrook | Steve Murphy |
| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Orejuela |
| Paulina Gaitan | Tata Escobar
(as Paulina Gaitán) |
| Raúl Méndez | César Gaviria |
| Manolo Cardona | Eduardo Sandoval |
| Cristina Umaña | Judy Moncada |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodriguez |
| Paulina GarcÃa | Hermilda Gaviria |
| Joanna Christie | Connie Murphy |
| Stephanie Sigman | Valeria Velez |
| Diego Cataño | La Quica |
| Leynar Gomez | Limon |
| Konstantin Melikhov | Edward Jacoby |
| Maurice Compte | Horacio Carrillo |
| Jorge Monterrosa | Trujillo
(as Jorge Monterroza) |
| Alejandro Buitrago | Velasco |
| Julián DÃaz | Blackie |
| Jairo Ordoñez | Jairo |
| Pedro Calvo | Gato |
| Juan Sebastián Calero | Navegante |
| Germán Jaramillo | Gustavo De Greiff |
| Mauricio Cujar | Don Berna |
| Luis Fernando Hoyos | Colonel Pinzón |
| Juan Murcia | Juan Pablo Escobar
(as Juan Sebastián Murcia) |
| MarÃa José Sanchez Real | Manuela
(as MarÃa José Sánchez) |
| DarÃo Cifuentes | David |
| Harby Rodriguez | Piraña |
| Carolina Acevedo | Gabriela |
| Johana Castaño | Gilberto's Secretary |
| José Restrepo | Sicario
(as Jose Restrepo) |
| Olga Garavito | David's Granny |
| Liseth Bitar | Mother |
| Miguel MartÃnez | Spotter 1 |
| Dubán Andrés Prado | Spotter 2
(as Dubán Prado) |
| Sebastián Cruz | Spotter 3 |
| Mateo Camacho | Shoe Shine Boy |
| Fernando Herrera | Young Recruit |
| Muratcan Savci | Fiscal de Muratcan |