| Wagner Moura | Pablo Escobar |
| Boyd Holbrook | Steve Murphy |
| Pedro Pascal | Javier Peña |
| Joanna Christie | Connie Murphy |
| Maurice Compte | Horacio Carrillo |
| Raúl Méndez | César Gaviria |
| Manolo Cardona | Eduardo Sandoval |
| Paulina Gaitan | Tata Escobar
(as Paulina Gaitán) |
| Paulina GarcÃa | Hermilda Gaviria |
| Alberto Ammann | Pacho Herrera |
| Patrick St. Esprit | Major Wysession |
| Danielle Kennedy | Ambassador Noonan |
| Richard T. Jones | Agent DEA |
| Julián DÃaz | El Negro |
| Christian Tappan | Kiko Moncada |
| Orlando Valenzuela | William Galeano |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Alejandro Buitrago | Velasco |
| Cristina Umaña | Judy Moncada |
| Vera Mercado | Ana Gaviria |
| Juan Murcia | Juan Pablo Escobar |
| Andrés Felipe MartÃnez | General Jaramillo
(as Andres Felipe) |
| Jorge Monterrosa | Trujillo
(as Jorge Monterosa) |
| Luis Miguel Hurtado | El Paisa |
| Oscar González | Polo
(as Oscar Gonzalez) |
| Rodrigo Celis | Sugar
(as Rodrigo Cellis) |
| Rafael Rodriguez | El Mugre |
| Javier Gardeazábal | Cali Sicario (Maicol)
(as Javier Gardeazabal) |
| Juan Carlos Arango | General Ariza |
| Carlos Martinez | Taxi Driver |
| Ricardo Niño | El Espectador Reporter |
| Silvio Plaza | Military Sergeant |
| Julieta Cardona | Natalie's Baby |
| Alejandra Crispin | Gaviria's Secretary |
| MarÃa José Sanchez Real | Manuela |
| Jairo Ordoñez | Pablo Sicario 1 |
| Alejandro Gomez | Pablo Sicario 2 |
| Alejandro Rubio | Pablo Sicario 3 |
| Javier Rodriguez | Pablo Sicario 4 |
| Milton Lopez | Pablo Sicario 5 |
| Julian Rodriguez | Major Baiz |
| Jason Chad Roth | Technician |
| Muratcan Savci | Fiscal de Muratcan |
| Stephanie Sigman | Valeria Velez |
| Nicolas Stan | Drug Cartel Boss Kid |