| Michael Peña | Enrique 'Kiki' Camarena |
| Diego Luna | Miguel Ángel Félix Gallardo |
| Tenoch Huerta | Rafael Caro Quintero |
| Alyssa Diaz | Mika Camarena |
| Joaquín Cosio | Ernesto 'Don Neto' Fonseca Carrillo |
| José María Yazpik | Amado Carrillo Fuentes |
| Matt Letscher | James Kuykendall |
| Aaron Staton | Butch Sears |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Gerardo Taracena | Pablo Acosta |
| Fermín Martínez | El Azul |
| Horacio Garcia Rojas | Tomás Morlet |
| Edmundo Vargas | Cuco |
| Guillermo Villegas | Sammy Álvarez |
| Tessa Ia | Sofía Conesa |
| Alejandro Bracho | Mr. X |
| Milton Cortés | Rubén Zuno Arce |
| Clark Freeman | Ed Heath |
| Yul Vazquez | John Gavin |
| Mark Kubr | Tony |
| Natasha Esca | Suzy |
| Luis Alberti | Verdin |
| Emilio Guerrero | Humberto Machaín |
| Fernando Ransom de la Torre | Juan |
| Pedro Hernández | Paco |
| Raúl Villegas | Pedro |
| Ricardo Esquerra | Mausoleum Salesman |
| Pilar Santacruz | Mr. X Secretary |
| Alan Alarcón | Maitre D' |
| Miguel Mena | Captain Ruiz |
| Ana Gonzalez Bello | Felix's Secretary |
| Kerry Ardra | Investigator #1 |
| Scoot McNairy | Narrator |
| Claudio Roca | (uncredited) |