| Michael Peña | Enrique 'Kiki' Camarena |
| Diego Luna | Miguel Ángel Félix Gallardo |
| Tenoch Huerta | Rafael Caro Quintero |
| Alyssa Diaz | Mika Camarena |
| Joaquín Cosio | Ernesto 'Don Neto' Fonseca Carrillo |
| José María Yazpik | Amado Carrillo Fuentes |
| Matt Letscher | James Kuykendall |
| Ernesto Alterio | Salvador Osuna Nava |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Gerardo Taracena | Pablo Acosta |
| Fernanda Urrejola | María Elvira |
| Teresa Ruiz | Isabella Bautista |
| Lenny Jacobson | Roger Knapp |
| Aaron Staton | Butch Sears |
| Julio Cesar Cedillo | Guillermo González Calderoni |
| Eric Lange | Bill Stechner |
| Fermín Martínez | El Azul |
| Horacio Garcia Rojas | Tomás Morlet |
| Guillermo Villegas | Sammy Álvarez |
| Tessa Ia | Sofía Conesa |
| Edmundo Vargas | Cuco |
| Jorge de los Reyes | Antonio Vargas |
| Clark Freeman | Ed Heath |
| Yul Vazquez | John Gavin |
| Fabrizio Santini | Javier Contreras |
| Edison Ruíz | Comandante Méndez |
| Sergio Jurado | César Conesa |
| Yuriria del Valle | Violeta Conesa |
| Alfonso Dosal | Benjamín Arellano Félix |
| Claudio Roca | Nicolás |
| Andrés Almeida | Cochiloco |
| Vladimir Cruz | Juan Matta Ballesteros |
| Gustavo Navarro | Comandante Rojas |
| Cuauhtli Jiménez | Guerrilla #1 |
| Juan Pablo de Santiago | Guerrilla #2 |
| Emiliano Clavel | Hotel Clerk |
| Alessandro Borrelli | Kiki Jr. |
| Ivana Plantier | Abril |
| Scoot McNairy | Narrator |