| Mike Colter | Luke Cage |
| Simone Missick | Misty Knight |
| Erik LaRay Harvey | Willis 'Diamondback' Stryker |
| Rosario Dawson | Claire Temple |
| Alfre Woodard | Mariah Dillard |
| Karen Pittman | Inspector Priscilla Ridley |
| Jacob Vargas | Domingo Colon |
| Michael Kostroff | Dr. Noah Burstein |
| Natalie Paul | Dana Stryker |
| Joniece Abbott-Pratt | Etta Lucas |
| Parisa Fitz-Henley | Reva Connors |
| Clark Jackson | Damon Boone |
| Darius Kaleb | Lonnie Wilson |
| Cassandra Freeman | Patricia Wilson |
| Justin Swain | Detective Mark Bailey |
| J. Bernard Calloway | Detective Dorsey |
| Lee R. Sellars | Sergeant Jacob 'Jake' Smith |
| Andrew Pang | Detective Donnie Chang |
| Rafael Benoit | Cameraman |
| Jeremiah Craft | D.W. Griffith |
| Gene Harrison | Officer Jackie Albini |
| Deborah Ayorinde | Candace |
| David Austin | Young Carl Lucas |
| Clifton Cutrary | Teenage Carl Lucas |
| Jared Kemp | Teenage Willis Stryker |
| Helmar Augustus Cooper | Reverend John Pope |
| Jennifer Brito | Female Uniformed Officer |
| Roger Wayne | Male Uniformed Officer |
| Thiree Pinnock | Angry Teen |
| Marquis Rodriguez | Darryl |
| Julian Rozzell Jr. | Vendor |
| Akua Santewa | Protester #1 |
| Anthony Vaughn Merchant | Protester #2 |
| Norma Aurel | Protester #3 |
| A.J. Franklin | Protester #4 |
| DeLance Minefee | Protester #5 |
| Ramon Aleman | Boxer #1 |
| Merritt Chase | Harlem Precinct Detective |
| Owen Rogers | Protester #8 |
| Justin Michael Woods | Protester |