| Mike Colter | Luke Cage |
| Mahershala Ali | Cornell 'Cottonmouth' Stokes |
| Simone Missick | Misty Knight |
| Theo Rossi | Hernan 'Shades' Alvarez |
| Erik LaRay Harvey | Willis 'Diamondback' Stryker |
| Rosario Dawson | Claire Temple |
| Alfre Woodard | Mariah Dillard |
| LaTanya Richardson Jackson | Mama Mabel |
| Ron Cephas Jones | Bobby Fish |
| Jacob Vargas | Domingo Colon |
| Karen Pittman | Inspector Priscilla Ridley |
| Sonja Sohn | Captain Betty Audrey |
| Danny Johnson | Ben Donovan |
| Curtiss Cook | Uncle Pete |
| Elijah Boothe | Young Cottonmouth |
| Megan Miller | Young Mariah |
| Clark Jackson | Damon Boone |
| Jaiden Kaine | Zip |
| Edwin Freeman | Young Pop |
| Michaela Jaé (MJ) Rodriguez | Sister Boy |
| Ephraim Sykes | Donnie |
| John Clarence Stewart | Alex Wesley |
| Justin Swain | Detective Mark Bailey |
| Dawn-Lyen Gardner | Megan McClaren |
| David Healy | Reporter 1 |
| Robyn Payne | Reporter 2 |
| Jeremiah Craft | D.W. Griffith |
| D-Nice | D-Nice |