| Charlie Cox | Matt Murdock |
| Deborah Ann Woll | Karen Page |
| Elden Henson | Foggy Nelson |
| Joanne Whalley | Sister Maggie |
| Jay Ali | Ray Nadeem |
| Vincent D'Onofrio | Wilson Fisk |
| Peter McRobbie | Father Lantom |
| Danny Johnson | Benjamin Donovan |
| Stephen Rowe | Nicholas Lee |
| Kate Udall | SAC Tammy Hattley |
| Sunita Deshpande | Seema Nadeem |
| Noah Huq | Sami Nadeem |
| Fajer Al-Kaisi | Nihar Nadeem
(as Fajer Kaisi) |
| Nandita Shenoy | Saanvi Nadeem |
| Dina Shihabi | Neda Kazemi |
| Chris Colombo | Mr. Kazemi |
| Jarrett Worley | Kidnapper |
| Jaxon Folds | Orphan #1 |
| Cheikh M'Baye | Orphan #2
(as Cheikh Tairou M'Baye) |
| Zenzi Williams | Nun |
| John Patrick O'Keefe | Taxi Driver |
| Evan Dane Taylor | Boxer |
| JaQuinley Kerr | Wealthy Guest
(uncredited) |
| Elodie Yung | Elektra Natchios
(archive footage) (uncredited) |