| Clark Gregg | Phil Coulson |
| Ming-Na Wen | Melinda May |
| Chloe Bennet | Daisy 'Skye' Johnson |
| Iain De Caestecker | Leo Fitz |
| Elizabeth Henstridge | Jemma Simmons |
| Henry Simmons | Alphonso 'Mack' Mackenzie |
| John Hannah | Holden Radcliffe
(credit only) |
| Gabriel Luna | Robbie Reyes /
Ghost Rider |
| Lilli Birdsell | Lucy Bauer |
| Dan Donohue | Frederick |
| Ward Roberts | Hugo |
| Usman Ally | Vincent |
| Daniel Zacapa | Canelo |
| Jason O'Mara | Jeffrey Mace |
| Briana Venskus | Agent Piper |
| Jen Sung | Chen
(as Jen Kuo Sung) |
| Nico David | Boy |
| John Churchill | Father |
| Adrian Quinonez | Ignacio
(as Adrian Quiñonez) |
| Deren Tadlock | Armed S.H.I.E.L.D. Guard |
| Mark Daneri | Wisconsin Congressman |
| Jenson Cheng | Chen's Gang #1 |
| Ken DuBois | Chen's Gang #2 |
| Victor Chi | Chen's Gang #3 |
| Edwin R. Habacon | Chen's Gang #4
(as Edwin H. Bravo) |
| Shayan Safar | S.H.I.E.L.D. Agent
(uncredited) |
| Jason Sweat | S.H.I.E.L.D. Agent
(uncredited) |