| Sam Worthington | Jim 'Fitz' Fitzgerald |
| Paul Bettany | Ted Kaczynski |
| Jeremy Bobb | Stan Cole |
| Lynn Collins | Natalie |
| Mark Duplass | David Kaczynski |
| Brían F. O'Byrne | Frank McAlpine |
| Ben Weber | Andy Genelli |
| Chris Noth | Don Ackerman |
| Katja Herbers | Linda Patrik |
| Rebecca Henderson | Judy Clarke |
| Mike Pniewski | Dr. Charles Epstein |
| Gregory Alan Williams | Judge Garland Burrell |
| Joe Knezevich | Steve Freccero |
| Bonnie Johnson | Wanda Kaczynski |
| Steve Coulter | Anthony Bisceglie |
| Dan Triandiflou | Gary Wright |
| Jana Allen | Heidi Shumway |
| McKenna Grace Martin | Joanna Epstein |
| Mary Rachel Quinn | Lois Epstein |
| Doug Kruse | Dr. David Gelernter |
| Pamela Ricardo | Court Clerk |
| Candace Mabry | Patrick Fischer's Secretary |
| Nonoma | FCI Prison Guard |
| Edward Youngberg | Intake Guard |
| Jill Remez | Susan Mosser |
| John Jacob Anderson | Stamp Guy |
| Lucie Carroll | Courtroom Observer |
| David Dickerson | Courtroom Audience |
| Jaxon Duron | US Marshal |
| Martin Feigen | UTF Agent |
| Mike D Harris | Courtroom Patron |
| Tony Koschmann | CBS News Reporter |
| Demetri Landell | Movie Goer & mall Shopper |
| Michael A. Leo | Prosecution Team |
| John Merical | UTF Agent |
| Matt Metzger | Courtroom Sketch Artist |
| Josh Royston | On-air Reporter |
| Patti Schellhaas | Courtroom News Reporter |
| Cade Smith | Doug Volkoff |
| Robert Tinsley | Police Officer |
| William Walker | UTF Agent |
| Russ Williamson | Trial Attendee |
| Lina Zalewski | Courtroom Audience Member |
| Perry Zulu Jr. | FBI Agent |