| Jon Hamm | Don Draper |
| Elisabeth Moss | Peggy Olson |
| Vincent Kartheiser | Pete Campbell |
| January Jones | Betty Draper |
| Christina Hendricks | Joan Holloway |
| Bryan Batt | Salvatore Romano |
| Michael Gladis | Paul Kinsey |
| Aaron Staton | Ken Cosgrove |
| Rich Sommer | Harry Crane
(credit only) |
| John Slattery | Roger Sterling |
| Mark Moses | Duck Phillips |
| Joel Murray | Fred Rumsen |
| Melinda McGraw | Bobbie Barrett |
| Gabriel Mann | Arthur Case |
| Alison Brie | Trudy Campbell |
| Peyton List | Jane Siegel |
| Rich Hutchman | Bud Campbell |
| Matt McKenzie | Crab Colson |
| Edmund L. Shaff | Chester Rockingham |
| Peter Jason | Len McKenzie |
| Alexandra Paul | Pauline Phillips |
| Gina DeVivo | Patricia Phillips |
| Kiernan Shipka | Sally Draper |
| Sarah Wright | Susie |
| Aaron Hart | Robert Draper |
| Julia Carpenter | Joyce |
| Miranda Lilley | Judy Campbell |
| Kim Swennen | Marcy Patterson |
| Jesse Henecke | Griz Patterson |
| Greg Felden | Webb |
| Jonathan Strait | Harold Wadro |
| Benjamin Seay | William Redd |
| Darian Weiss | Mark Phillips |
| Dawn Marie Anderson | Receptionist
(uncredited) |
| Dana Blackstone | Secretary
(uncredited) |
| Claire Bocking | Secretary
(uncredited) |
| Jenni Cardone | Audition Girl
(uncredited) |
| Chris Chamberlain | Army Major
(uncredited) |
| Eve Curtis | Secretary
(uncredited) |
| Jessica Doehle | Secretary
(uncredited) |
| Evelyn Edwards | Secretary
(uncredited) |
| Emelle | Secretary
(uncredited) |
| Molly Beck Ferguson | Secretary
(uncredited) |
| Britt Hysen | Mary
(uncredited) |
| Jennifer McGraw | Secretary
(uncredited) |
| Leigh Myles | Secretary
(uncredited) |
| Sarah Jannett Parish | Donna
(uncredited) |
| Arne Starr | The Artist
(uncredited) |
| Andrea VanEpps | Auditioning Woman
(uncredited) |
| Rima Yazbeck | Burlesque Dancer
(uncredited) |