| Louis C.K. | Louie |
| Robin Williams | Robin
(as Robin Willaims) |
| Hadley Delany | Lilly |
| Jeremy Shinder | Never Cartesian |
| Edward Gelbinovich | Doug |
| Artie Lange | Truck Driver |
| Nancy Shayne | Nancy Cartesian |
| J.B. Smoove | Gravedigger #2
(as JB Smoove) |
| Anthony Cumia | Tracer
(voice) |
| Gregg Hughes | Radio Show Producer
(voice) (as Greg 'Opie' Hughes) |
| Jim Norton | Pig
(voice) |
| Amy Schumer | Diane
(voice) |
| McKinley Belcher III | Gravedigger #1 |
| Ally Gordon | Stripper #1 |
| Uma Incrocci | Rug Stealing Woman |
| Minnie Lee | Stripper #4 |
| Dawn McGee | Screaming Woman |
| Jay Oakerson | Strip Club Emcee |
| Faina Reinhardt | Stripper #3
(as Faina Vitebsky Reinhardt) |
| Whitney White | Stripper #2
(as Whitney Claire White) |
| Lulu Wilson | Little Girl |
| Hye Jin Jang | Stripper
(as Hyejin J.) |
| Antonio E. Moreno | Guy at Strip Club
(uncredited) |