| Adrian Dunbar | Hastings |
| Paul Higgins | Hilton |
| Martin Compston | Steve |
| Syreeta Kumar | Trauma Consultant |
| Mark Stobbart | Neil |
| Thandiwe Newton | Roz
(as Thandie Newton) |
| Claudia Jessie | Jodie |
| Anneika Rose | Farida |
| Nigel Boyle | Buckells |
| Maya Sondhi | Maneet |
| Vicky McClure | Kate |
| Royce Pierreson | Jamie |
| Vineeta Rishi | Rupal |
| Patrick Baladi | Jimmy |
| Lee Ingleby | Nick |
| Scott Reid | Michael |
| Henry Miller | Morganstaff |
| Mary Healey | Eileen |
| Jason Watkins | Tim |
| Pandora Colin | Surgical Staff Nurse |
| Craig Parkinson | DI Matthew Cottan |
| Gina McKee | Jackie Laverty
(archive footage) (uncredited) |
| Simon Millar | Brightway
(uncredited) |
| Arlene Martine Morris | Physiotherapist
(uncredited) |
| Jude North | CSI Officer Bloom
(uncredited) |
| Sakuntala Ramanee | Dr. Patel
(archive footage) (uncredited) |