| Jerry Orbach | Detective Lennie Briscoe |
| Jesse L. Martin | Detective Ed Green |
| S. Epatha Merkerson | Lieutenant Anita Van Buren |
| Sam Waterston | E.A.D.A. Jack McCoy |
| Angie Harmon | A.D.A. Abbie Carmichael |
| Dianne Wiest | Interim D.A. Nora Lewin |
| Robert Emmet Lunney | Bill Semple |
| Mia Dillon | Patricia Semple |
| Michael Shulman | Kevin Miller |
| Timothy Reifsnyder | Henry Semple |
| Doris Belack | Trial Judge Margaret Barry |
| Marisa Redanty | Principal |
| Greg Wood | Semple's Public Defender |
| J.K. Simmons | Dr. Emil Skoda |
| Carey Lowell | Defense Attorney Jamie Ross |
| David Lipman | Arraignment Judge Morris Torledsky |
| Michelle Hurst | Simone Adams |
| Kevin Davis | John Laramie |
| Elizabeth Kemp | Laila Jacobs |
| Halley Feiffer | Colleen Jacobs |
| Colin Fickes | Paul |
| Mary Kaye Swedish | Dr. Helena Forsythe |
| Les McDonough | Mr. Miller |
| Rudy Roberson | Lonnie Nolan |
| Lyndsey Watkins | Linda Johnson |
| Sebastian Sozzi | Tommy Gutierrez |
| Christopher Knowings | Brian Anders |
| Nancy Ticotin | Detective Reina Perez |
| Neal Hemphill | Father #1 |
| Don Clark Williams | Father #2 |
| Fermín Suárez | Father #3 |
| Dee Pelletier | Mother #1 |
| Gretha Boston | Mother #2 |
| Michael Winther | Reporter |
| Michael E. Lopez | Max Roberts |
| Kate Greer | Linda Fox |
| Freddie L. Robinson Jr. | John Reese |
| Olivia Oguma | Melanie Hsu |
| Pamela Bel Anu | Uniform Policewoman |
| Terianne Flacone | Mrs. Miller |
| David Sajadi | Uniform Policeman |
| Sanjiv Jhaveri | Clerk |
| Jeannine Comeau | Paralegal |
| Joyce Lee | Foreperson |
| Tamara Torres | Woman |
| Albert E. King | Howard Earl |
| Nicholas M. Garofolo | Father #4 |
| Steven Zirnkilton | Narrator |