| Gina Rodriguez | Jane Villanueva |
| Andrea Navedo | Xiomara Villanueva |
| Yael Grobglas | Petra Solano |
| Justin Baldoni | Rafael Solano |
| Ivonne Coll | Alba Villanueva |
| Elias Janssen | Mateo Solano Villanueva |
| Jaime Camil | Rogelio De La Vega |
| Yara Martinez | Dr. Luisa Alver |
| Justina Machado | Darci Factor |
| Diane Guerrero | Lina |
| Priscilla Barnes | Magda |
| Castulo Guerra | Grandpa De La Vega |
| Keller Wortham | Esteban |
| Melanie Mayron | Marlene Donaldson |
| Jenna Ortega | Young Jane |
| Rita Moreno | Liliana De La Vega |
| Anthony Mendez | Narrator |
| Rosario Dawson | Jane Ramos |
| Mia Allan | Anna |
| Ella Allan | Ellie |
| Cali DiCapo | 11 Year Old Jane |
| Julianna Gamiz | 5 Year Old Jane |
| Shelly Bhalla | Krishna |
| Alfonso DiLuca | Jorge |
| Joshua Chang | Danny |
| Ray Reynaga | Worker |
| Tai Brown | Runner |
| Jon Southwell | Bus Driver |
| Cheryl Francis Harrington | Chantelle |
| Christopher Mychael Watson | American Runner |
| Emily Baldoni | Runner Friend |
| Eduardo Lezcano | Church Goer |
| Amber Martinez | Marathon Runner |
| Jessica Nunez-Wood | Wedding Guest |
| Mickey O'Connor | Marathon Runner #1 |
| Edward Redmond | Marathon Runner |
| Brittney Renee | Wedding Attendee |
| Nate Luis Silva | Spectator |
| Alfredo Tavares | Eastern European Investor |
| Jeffrey Lynn White Jr. | Fan |