| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Tom Verica | Sam Keating |
| Amirah Vann | Tegan Price |
| David Andrews | Hugh Murphy |
| Yolonda Ross | Claudia Gelvin |
| Judith Scott | Barham |
| Behzad Dabu | Simon Drake |
| Michael Reilly Burke | Louis Lindgren |
| Jimmy Smits | Isaac Roa |
| Kim Delgado | Judge Howard Walker |
| Terry Woodberry | Rex Morris |
| Cuete Yeska | Manuel Soto |
| Doc Farrow | Seasoned Male Inmate |
| Charisse Woodall | Evelyn Park |
| Liza Fernandez | Witness Advocate |
| Scott Broderick | Quiet Male Inmate |
| Liz Eldridge | Female Inmate #3 |
| Connie Schiro | Tough Female Inmate |
| Joshua Chang | Reporter #1 |
| Anahi Bustillos | Reporter #2 |
| Alysia Livingston | Reporter #3 |
| Katia Gomez | Officer Peterson |
| Anthony Quinn Williams | Security Guard
(as Anthony Q. Williams) |
| Alfred Enoch | Wes Gibbins
(archive footage) (uncredited) |
| Intae Kim | Detective Fisher
(uncredited) |