| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Diane Lane | Annette Shepherd |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Boris McGiver | Tom Hammerschmidt |
| Derek Cecil | Seth Grayson |
| Greg Kinnear | Bill Shepherd |
| Cody Fern | Duncan Shepherd |
| Constance Zimmer | Janine Skorsky |
| Jayne Atkinson | Catherine Durant |
| Chip Zien | Dr. Charles Rosen |
| Linda Powell | Marcy Siegerson |
| Athena Karkanis | Melody Cruz |
| Brian Keane | Ray Meyers |
| Kristen Sieh | Kelsey Stewart |
| Thomas Kopache | Earl Hanna |
| Marc Kudisch | Henry Mitchell |
| Darwin Shaw | Rafiq Nasser |
| Jeremy Holm | Nathan Green |
| Gregg Edelman | Stan Durant |
| Ali Collier | Teen Claire |
| Abby Rose Merrill | Teen Annette
(as Abby Merrill) |
| Susan Pourfar | Nora Cafferty |
| Linda Marie Larson | Jennifer Baumgarten |
| David Price | Fred Amburg |
| Steve Blanchard | Senator |
| Eli Goodman | Wayne Snyder |
| Monica Sanchez | Consuela Munroe |
| David Gregory | David Gregory |
| Lawrence O'Donnell | Lawrence O'Donnell |
| Martha Raddatz | Martha Raddatz |
| Matthew Dowd | Matthew Dowd |
| Stephanie Cutter | Stephanie Cutter |
| Alisyn Camerota | Alisyn Camerota |
| John Berman | John Berman |
| Wolf Blitzer | Wolf Blitzer |
| Jon Shaver | Cabinet Member
(as John Shaver) |
| Tim Pabon | Reporter |
| Stephanie Umoh | Reporter |
| Julie Mun | Reporter |
| Jenny Gulley | Reporter |
| Nini Le Huynh | Lynn Phang |
| Angelo Reyes | Bellhop |
| Anna Magoulas | Special Agent Wenniger |
| Tim Moriarty | Special Agent Gilbar |
| Pat Dortch | Secretary of Energy |
| Edward Incle | Lieutenant Quintero
(as Ed Incle) |
| Molly Nugent | Ray's Daughter |
| Jackie McClain | Cabinet Member |
| Antoinette Montgomery | White House Press Corps |
| Robert Olausen | White House Press Photographer |
| Janae Palmer | Airport Commuter |
| Stephen C. Poland | Usher's Cabinet |
| Alan Tilles | Cabinet Secretary |
| Debbie Tsamoudakis | FBI Agent |
| Charlita Woodruff | White House Press Corp |
| Matthew Bernard | Press
(uncredited) |
| Marisol Correa | Victim
(uncredited) |
| Riaz Dhanani | Diplomat
(uncredited) |
| Mark Falvo | White House Press Corps
(uncredited) |
| Dave Ferrier | Videographer
(uncredited) |
| Ryan Hinson | Governor's Guest
(uncredited) |
| Gina Jun | Staff
(uncredited) |
| Anita Moore | Lady Cabinet
(uncredited) |
| Spencer Trinwith | Affluent Trust Fund Guy
(uncredited) |
| Dennis Wildberger | Traveler at Airport
(uncredited) |