| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Boris McGiver | Tom Hammerschmidt |
| Korey Jackson | Sean Jeffries |
| Jayne Atkinson | Catherine Durant |
| Larry Pine | Bob Birch |
| Curtiss Cook | Terry Womack |
| Wendy Moniz | Laura Moretti |
| Jeremy Holm | Nathan Green |
| James Martinez | Alex Romero |
| Malcolm Madera | Eric Rawlings |
| Alexis Nichole Smith | Angela |
| Jennifer Riker | Maureen Shaud |
| Rachel Maddow | Rachel Maddow |
| Tom Kemp | Editor in Chief |
| John Moon | Editor #1 |
| Artie Brennan | IT Guy |
| Nikki Estridge | Female Agent |
| Chagmion Antoine | Newscaster |
| Jessica Abo | Anchor |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Dennis P. Marburger | Restaurant Customer
(uncredited) |
| Jeffrey Mowery | Herald Photographer
(uncredited) |
| Vanessa Quinlivan | Party Guest
(uncredited) |
| Michael Rubino | Pundit #2
(uncredited) |