| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Boris McGiver | Tom Hammerschmidt |
| Korey Jackson | Sean Jeffries |
| Jayne Atkinson | Catherine Durant |
| Michel Gill | Garrett Walker |
| Damian Young | Aidan Macallan |
| Jeremy Holm | Nathan Green |
| James Martinez | Alex Romero |
| Kate Lyn Sheil | Lisa Williams |
| Paton Ashbrook | Bridget Cohen |
| Cindy Cheung | Meredith Lee |
| Joey Auzenne | Vern |
| Nini Le Huynh | Claire's Aide |
| Martin Barabas | Walker's Lawyer |
| Kody Kight | Protestor |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Dave Ferrier | Videographer
(uncredited) |
| Ben Hammock | DC Driver /
Pedestrian
(uncredited) |
| Jamie Hodge | Coffee Shop Jogger
(uncredited) |
| George Ludden | Congressman
(uncredited) |
| Jeffrey Mowery | Herald Photographer
(uncredited) |