| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Boris McGiver | Tom Hammerschmidt |
| Jayne Atkinson | Catherine Durant |
| Kim Dickens | Kate Baldwin |
| Damian Young | Aidan Macallan |
| Lars Mikkelsen | Viktor Petrov |
| Curtiss Cook | Terry Womack |
| James Martinez | Alex Romero |
| Mark Borkowski | Ted Barnes |
| Malcolm Madera | Eric Rawlings |
| Svetlana Efremova | Nadia Surkova |
| Alexis Nichole Smith | Angela |
| Van Jones | Van Jones |
| S.E. Cupp | S.E. Cupp |
| Gloria Borger | Gloria Borger |
| Michael Gabel | Chief Justice |
| Max Firestein | Russian Teen |
| Matthew Bernard | Supporter
(uncredited) |
| Rick Kelvin Branch | Inaguration Acceptance Speach Guest
(uncredited) |
| Loretta Burnette | Inauguration Guest
(uncredited) |
| Stephanie Cookie Carson | Inauguration Guest
(uncredited) |
| Iris Crenshaw | Political Guest
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Seth Kozak | Brigadier General
(uncredited) |
| George Ludden | Bystander
(uncredited) |
| Gemma McIlhenny | Congresswoman
(uncredited) |
| Jeffrey Mowery | Herald Photographer
(uncredited) |
| Phil Notarange | Cabinet Member
(uncredited) |
| Andy Rivera | Inauguration VIP
(uncredited) |
| Carly Tamborski | Inauguration Guest
(uncredited) |