| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Paul Sparks | Thomas Yates |
| Boris McGiver | Tom Hammerschmidt |
| Gerald McRaney | Raymond Tusk |
| Jayne Atkinson | Catherine Durant |
| Colm Feore | Ted Brockhart |
| Lars Mikkelsen | Viktor Petrov |
| Daniel Sauli | Benjamin Grant |
| Mercedes Herrero | Vanessa Morrison |
| Kevin Carrigan | Admiral Dale |
| Susan Pourfar | Nora Cafferty |
| Phil Nee | Xu Jiabao |
| Alexis Nichole Smith | Angela |
| Nini Le Huynh | Claire's Aide |
| Andrew Hunsicker | The Man |
| Gord James | Newscaster #1
(as Gordon James) |
| Michelle Davidson | Newscaster #2 |
| Connor Berry | Inquesitive Student |
| Adam DeMarco | Valet |
| Zachary Schwartz | Young Tech Artist |
| William G. Tomek | Iowa Governor
(as Bill Tomek) |
| Garrick Wimbush | Billionaire |
| Elaina Adrianna | Dead Redhead
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Greg Harvey | High Priest
(uncredited) |
| Jeffrey Mowery | Herald Photographer
(uncredited) |
| Alex Sanon | Billionaire Camper
(uncredited) |