| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Patricia Clarkson | Jane Davis |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Dominique McElligott | Hannah Conway |
| Boris McGiver | Tom Hammerschmidt |
| Korey Jackson | Sean Jeffries |
| Jayne Atkinson | Catherine Durant |
| Wendy Moniz | Laura Moretti |
| Julian Gamble | Col. Max Braegher |
| Mercedes Herrero | Vanessa Morrison |
| Jeremy Holm | Nathan Green |
| Susan Pourfar | Nora Cafferty |
| Kenneth Tigar | Walter Doyle |
| Alexis Nichole Smith | Angela |
| John Rue | CIA Director |
| Robert Poletick | Secretary of Defense |
| Aaron Costa Ganis | Secret Service Agent |
| Kimberly S. Fairbanks | Reporter
(as Kimberly Fairbanks) |
| Valerie Grace | White House Press Photographer |
| Jay McCord | White House Press Corps |
| Bobby Plasencia | Super |
| Yasmin Qudah | Photographer |
| Matthew Bernard | Press
(uncredited) |
| Cody Cooley | Reporter
(uncredited) |
| Gregory Divers | White House Press Corps
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Melissa Dudek | White House Press Corp
(uncredited) |
| Dave Ferrier | Videographer
(uncredited) |
| Gina Jun | Staff
(uncredited) |